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KMID : 0361720140250030195
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Korean Journal of perinatology
2014 Volume.25 No. 3 p.195 ~ p.201
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A Case of Herpes Simplex Virus Type 2 Encephalitis of a Newborn Delivered by a Mother without Prenatal Screening
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Lee Eun-Seob
Kim Joon-Young
Lee Kon-Hee
Lee Jung-Won
Lee Yong-Ju
Oh Yeon-Joung
Bang Ji-Seok
Sung Tae-Jung
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Abstract
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Neonatal herpes simplex virus (HSV) encephalitis is a rare disease nowadays because of prenatal screening test and management. It shows progressive central nervous system manifestations affecting predominantly temporal and frontal lobes. Early diagnosis of HSV encephalitis is important since even with the early initiation of high-dose intravenous acyclovir therapy, it results in serious morbidity among survivors. A 14-day-old neonate with fever and poor oral intake was admitted via emergency department. The next day she had seizures and the brain was damaged with permanent sequelae despite of early administration of intravenous acyclovir on day 2 of admission. We report a serious case of HSV encephalitis diagnosed as type 2 HSV by PCR and culture of a newborn who was delivered by a mother without proper prenatal screening test.
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KEYWORD
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Encephalitis, Herpes Simplex, Newborn
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